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CISDOC database

Document ID (ISN)21861
CIS number 74-1928
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1974
Convention or series no.
Author(s) Singh A.R., Lawrence W.H., Autian J.
Title Mutagenic and antifertility sensitivities of mice to di-2-ethylhexyl phthalate (DEHP) and bis(methoxyethyl) phthalate (DMEP).
Bibliographic information July 1974, Vol.29, No.1, p.35-46. 28 ref.
Abstract Numerous plastic materials used for medical and paramedical applications as well as for food processing and packaging are made of polyvinyl chloride. To provide the desirable physical characteristics, significant quantities of plasticisers are added. One commonly used group of plasticisers is the phthalic acid esters, probably the most widely used. It is known that small quantities of plasticisers can be leached from such materials by blood, milk and other solutions. This communication presents the results of dominant lethal mutation and antifertility studies on bis(2-ethylhexyl) phthalate and dimethoxyethyl phthalate in mice. These 2 phthalate esters produced some degree of dose-dependent and time-dependent antifertility and mutagenic effects.
Descriptors (primary) mutagenic effects; plasticizers; phthalates; polyvinyl chloride
Descriptors (secondary) antifertility effects; animal experiments; bis(methoxyethyl) phthalate; bis(ethylhexyl) phthalate
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Phthalates
Esters and salts
Genetic factors in reaction to exposures