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Document ID (ISN)21592
CIS number 74-1646
ISSN - Serial title 0009-9309 - Clinical Toxicology
Year 1974
Convention or series no.
Author(s) Sidell F.R.
Title Soman and sarin: Clinical manifestations and treatment of accidental poisoning by organophosphates.
Bibliographic information Feb. 1974, Vol.7, No.1, p.1-17. Illus. 20 ref.
Abstract Description of 4 cases of accidental exposure to the potent cholinesterase inhibitors sarin (isopropylmethylphosphonofluoridate) and soman (pinacolylmethylphosphonofluoridate). An account is given in each case of the initial clinical manifestations, the therapy instituted and the reactions to therapy. It was observed that: (1) there were psychiatric sequelae in the 2 most severe cases; (2) scopolamine, which disrupts mental performance in normal subjects, ameliorated the mental condition in the patient to whom it was administered, indicating that this drug deserves further evaluation under similar circumstances; (3) the soman-inhibited circulating cholinesterases in one case were refractory to reactivation by pralidoxime chloride, confirming that the effectiveness of the oxime varies with the inhibitor.
Descriptors (primary) sarin; Soman; mental disorders; insecticides; toxicology; organophosphorus compounds
Descriptors (secondary) enzyme inhibition; case study; chemotherapy; medical treatment; cholinesterase
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Mental health
Esters and salts