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Document ID (ISN)21436
CIS number 74-1421
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1974
Convention or series no.
Author(s) Carter M.K., Maddux B.
Title Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases.
Bibliographic information Feb. 1974, Vol.27, No.2, p.456-463. Illus. 24 ref.
Abstract The in vitro interaction of several anticholinesterase pesticides and chlorpromazine with dichlorvos on the inhibition of human blood cholinesterase was investigated. The data presented indicate that in vitro combinations of dichlorvos with selected anticholinesterases usually result in less inhibition when compared to the calculated summed individual inhibitions. Only in the case of the combination of chlorpromazine with dichlorvos, using human red blood cells as a source of cholinesterase, was the combined inhibition greater than the summed individual inhibitions. Explanations are offered for the increased inhibition of cholinesterase that is reported here for dichlorvos and chlorpromazine and the increased toxicity reported by others for other organophosphate agents and chlorpromazine.
Descriptors (primary) dichlorvos; cholinesterase; synergism; pesticides; enzyme disturbances
Descriptors (secondary) chlorpromazine; comparative study; in vitro experiments
Document type -
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Esters and salts