| Document ID (ISN) | 21436 |
| CIS number |
74-1421 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Carter M.K., Maddux B. |
| Title |
Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases. |
| Bibliographic information |
Feb. 1974, Vol.27, No.2, p.456-463. Illus. 24 ref. |
| Abstract |
The in vitro interaction of several anticholinesterase pesticides and chlorpromazine with dichlorvos on the inhibition of human blood cholinesterase was investigated. The data presented indicate that in vitro combinations of dichlorvos with selected anticholinesterases usually result in less inhibition when compared to the calculated summed individual inhibitions. Only in the case of the combination of chlorpromazine with dichlorvos, using human red blood cells as a source of cholinesterase, was the combined inhibition greater than the summed individual inhibitions. Explanations are offered for the increased inhibition of cholinesterase that is reported here for dichlorvos and chlorpromazine and the increased toxicity reported by others for other organophosphate agents and chlorpromazine. |
| Descriptors (primary) |
dichlorvos; cholinesterase; synergism; pesticides; enzyme disturbances |
| Descriptors (secondary) |
chlorpromazine; comparative study; in vitro experiments |
| Document type |
- |
| Subject(s) |
Agriculture, fishing, animal husbandry
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Blood diseases
Esters and salts
|
