| Document ID (ISN) | 21347 |
| CIS number |
74-1354 |
| ISSN - Serial title |
0025-7818 - Medicina del lavoro |
| Year |
1973 |
| Convention or series no. |
|
| Author(s) |
Lancranjan I. |
| Title |
Changes of the corticosuprarenal function induced by chronic carbon disulphide poisoning. |
| Bibliographic information |
Sep.-Oct. 1973, Vol.64, No.9-10, p.375-380. 11 ref. |
| Abstract |
The adrenal function of 99 young men (79 with chronic carbon disulfide poisoning, 20 with no exposure to organic solvents) was studied. All of those poisoned had a neurasthenic syndrome, 8 suffered from toxic encephalopathy and 55 were affected by sensorimotor polyneuritis. The endocrinological study (determination of urinary concentrations of 17 hydrocorticosteroids and 17 ketosteroids) revealed the existence of an adrenal insufficiency in 50 subjects (64%). 2 forms of this insufficiency were disclosed: a) a central form due to a reduced secretion of ACTH, and b) a peripheral form with lesions of the suprarenal capsule. The pathogenesis of this disorder is complex: CS2 disturbs the neurohormonal control mechanism, thus causing suprarenal lesions. The study also disclosed a disturbance in circadian rhythm, assumed to be due to a disorder of the central nervous system. Systematic surveillance of these endocrine changes could provide criteria for the diagnosis and study of the evolution of poisoning, and for determining its severity. |
| Descriptors (primary) |
carbon disulfide; adrenal function; toxicology |
| Descriptors (secondary) |
neurotoxic effects; adrenal insufficiency; encephalopathy; comparative study; polyneuritis; circadian rhythm; survey; neurasthenia |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Inorganic sulfur compounds
Inorganic substances
|
