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Document ID (ISN)21223
CIS number 74-1313
ISSN - Serial title 0004-1254 - Arhiv za higijenu rada i toksikologiju
Year 1973
Convention or series no.
Author(s) Pleština R., Svetličić B.
Title Toxic effects of two carbamate insecticides in dogs.
Bibliographic information 1973, Vol.24, No.3, p.217-225. Illus. 19 ref.
Abstract The authors observed a difference in duration of plasma cholinesterase inhibition in workers exposed to propoxur (2-isopropoxyphenyl methylcarbamate) and promecarb (3-methyl-5-isopropylphenyl-N-methylcarbamate). To find out whether this difference is due to the enzyme-inhibitor interaction or to differences in absorption, they administered equitoxic doses of the 2 carbamates to dogs by intravenous and intramuscular injections. While a difference in inhibition duration was found only after intramuscular injection, the enzyme activity recovery was similar for both carbamates after intravenous injection. The delayed plasma cholinesterase recovery after promecarb administration was due to the much slower absorption of the compound after intramuscular injection.
Descriptors (primary) carbamates; toxicology; insecticides; enzyme disturbances
Descriptors (secondary) metabolic process; animal experiments; promecarb; arprocarb
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Amides