| Document ID (ISN) | 21222 |
| CIS number |
74-1312 |
| ISSN - Serial title |
0004-1254 - Arhiv za higijenu rada i toksikologiju |
| Year |
1973 |
| Convention or series no. |
|
| Author(s) |
Simeon V., Reiner E. |
| Title |
Comparison between inhibition of acetylcholinesterase and cholinesterase by some N-methyl- and NN-dimethyl-carbamates. |
| Bibliographic information |
1973, Vol.24, No.3, p.199-206. 21 ref. |
| Abstract |
The authors established second order rate constants (ka) for the inhibition of acetylcholinesterase and cholinesterase in various media (human and animal sera and erythrocytes) by 7 N-methylcarbamates and 2 NN-dimethylcarbamates; the values obtained are tabulated. A comparison between the 2 enzyme activities in pre-steady state (based on ka values) and in steady state (based on apparent equilibrium constants for enzyme and inhibitor) showed that the difference in degree of inhibition by the same compound in the steady and pre-steady states is proportional to the difference in stability of the carbamylated enzymes. |
| Descriptors (primary) |
carbamates; insecticides; enzyme disturbances |
| Descriptors (secondary) |
acetylcholinesterase; cholinesterase; comparative study; human experiments; animal experiments |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Blood diseases
Amides
|
