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Document ID (ISN)21222
CIS number 74-1312
ISSN - Serial title 0004-1254 - Arhiv za higijenu rada i toksikologiju
Year 1973
Convention or series no.
Author(s) Simeon V., Reiner E.
Title Comparison between inhibition of acetylcholinesterase and cholinesterase by some N-methyl- and NN-dimethyl-carbamates.
Bibliographic information 1973, Vol.24, No.3, p.199-206. 21 ref.
Abstract The authors established second order rate constants (ka) for the inhibition of acetylcholinesterase and cholinesterase in various media (human and animal sera and erythrocytes) by 7 N-methylcarbamates and 2 NN-dimethylcarbamates; the values obtained are tabulated. A comparison between the 2 enzyme activities in pre-steady state (based on ka values) and in steady state (based on apparent equilibrium constants for enzyme and inhibitor) showed that the difference in degree of inhibition by the same compound in the steady and pre-steady states is proportional to the difference in stability of the carbamylated enzymes.
Descriptors (primary) carbamates; insecticides; enzyme disturbances
Descriptors (secondary) acetylcholinesterase; cholinesterase; comparative study; human experiments; animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Amides