Document ID (ISN) | 21045 |
CIS number |
74-1050 |
ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
Year |
1973 |
Convention or series no. |
|
Author(s) |
Muacevic G. |
Title |
Acute toxicity and cholinesterase inhibition in vivo of bromophos-ethyl. |
Bibliographic information |
June 1973, Vol.25, No.2, p.180-189. Illus. 17 ref. |
Abstract |
This report is intended to facilitate the handling of the insecticide bromophos-ethyl (0-(4-bromo-2,5-dichlorophenyl)-0,0-diethyl phosphorothioate) and to indicate suitable antidotes in case of poisoning. Tests were carried out on mice, rats and other animal species with a view to determining acute toxicity, mucosal compatibility, neurotoxicity, antagonism and synergism, and inhibition of cholinesterase. Results indicate that bromophos-ethyl is among the phosphorus acid esters showing moderate toxicity. In combination with certain organic phosphorus acid esters, toxicity is increased; chlorinated hydrocarbons reduce the toxicity. Reactivation of the cholinesterase is possible with oximes (obidoximechloride, trimedoximebromide) especially in combination with atropine. |
Descriptors (primary) |
acute toxicity; insecticides; enzyme disturbances; organic thiophosphates |
Descriptors (secondary) |
atropine; cholinesterase; oximes; synergism; antidote treatment; animal experiments; bromophos-ethyl |
Document type |
- |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
|
Browse category(ies) |
Blood diseases Esters and salts Agricultural chemicals
|