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CISDOC database

Document ID (ISN)21045
CIS number 74-1050
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1973
Convention or series no.
Author(s) Muacevic G.
Title Acute toxicity and cholinesterase inhibition in vivo of bromophos-ethyl.
Bibliographic information June 1973, Vol.25, No.2, p.180-189. Illus. 17 ref.
Abstract This report is intended to facilitate the handling of the insecticide bromophos-ethyl (0-(4-bromo-2,5-dichlorophenyl)-0,0-diethyl phosphorothioate) and to indicate suitable antidotes in case of poisoning. Tests were carried out on mice, rats and other animal species with a view to determining acute toxicity, mucosal compatibility, neurotoxicity, antagonism and synergism, and inhibition of cholinesterase. Results indicate that bromophos-ethyl is among the phosphorus acid esters showing moderate toxicity. In combination with certain organic phosphorus acid esters, toxicity is increased; chlorinated hydrocarbons reduce the toxicity. Reactivation of the cholinesterase is possible with oximes (obidoximechloride, trimedoximebromide) especially in combination with atropine.
Descriptors (primary) acute toxicity; insecticides; enzyme disturbances; organic thiophosphates
Descriptors (secondary) atropine; cholinesterase; oximes; synergism; antidote treatment; animal experiments; bromophos-ethyl
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Esters and salts