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CISDOC database

Document ID (ISN)20834
CIS number 74-674
ISSN - Serial title 0013-9351 - Environmental Research
Year 1973
Convention or series no.
Author(s) Zaidi S.H., Dogra R.K.S., Shanker R., Chandra S.V.
Title Experimental infective manganese pneumoconiosis in guinea pigs.
Bibliographic information Sep. 1973, Vol.6, No.3, p.287-297. Illus. 30 ref.
Abstract To assess the role of an infective factor in the production of manganese pneumoconiosis, guinea pigs were intratracheally inoculated with only Candida ablicans (a facultative pathogen of the upper respiratory tract), only manganese dioxide or a combination of both. Histopathological studies revealed at the termination of the experiments (180 days) that the dust and organism together produced thick reticulin and collagen fibrosis in the lungs; manganese dioxide alone produced a fibrotic reaction comprised of only thick reticulin fibres, while the organism alone produced slight lymphoid hyperplasia and no fibrosis.
Descriptors (primary) manganese dioxide; Candida albicans; manganese pneumoconiosis; dust; infectious diseases
Descriptors (secondary) connective tissue development; histopathology; animal experiments
Document type -
Subject(s) Dust, aerosols and related diseases
Broad subject area(s)
Browse category(ies) Pneumoconioses
Inorganic substances
Bacterial and parasitic diseases