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CISDOC database

Document ID (ISN)20151
CIS number 74-151
ISSN - Serial title 0020-5923 - Internationales Archiv für Arbeitsmedizin - International Archives of Occupational Health
Year 1973
Convention or series no.
Author(s) Grigorowa R., Binnewies S., Gohlke R.
Title Combined action of organophosphorus pesticides and increased environmental temperature in short-term inhalation studies in the rat
Original title Über die kombinierte Wirkung von phosphororganischen Pestiziden und erhöhter Umgebungstemperatur in inhalatorischen Kurzversuchen an Ratten [in German]
Bibliographic information 31 Aug. 1973, Vol.31, No.4, p.295-327. Illus. 39 ref.
Abstract The combined action of 3 different organophosphate pesticides and increased environmental temperature (35°C, 50% relative humidity) was investigated in subacute (8 days) inhalation experiments with male rats. In the first part of the study, toxicological aspects are discussed in relation to the following parameters: relative weight of organs, cholinesterase activity, total protein and protein fractions in serum, cell respiration in homogenised liver tissue, ACTH activity of the pituitary gland, body weight and body temperature. Most of the parameters examined revealed an increase in toxicity due to combined exposure. In the second part of the study, the results of histological, histochemical and morphologic studies are described: histology in lung, liver and thyroid, enzyme histochemistry in the liver, morphometry and storage of 131I in the thyroid. The results confirmed in general the increased effect of these pesticides at high environmental temperature.
Descriptors (primary) toxic effects; hot workplaces; pesticides; phosphoric acid esters
Descriptors (secondary) Tinox; dimethoate; inhalation; methyl parathion; synergism; heat; animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Heat and cold
Esters and salts