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Document ID (ISN)19655
CIS number 72-2695
ISSN - Serial title 0363-0153 - Archives of Pathology
Year 1971
Convention or series no.
Author(s) Dalldorf F.G., Kaufmann A.F., Brachman P.S.
Title Woolsorters' disease - An experimental model
Bibliographic information Dec. 1971, Vol.92, p.418-426. Illus. 27 ref.
Abstract Description of an experimental model of inhalation anthrax in monkeys that very closely mimics woolsorters' disease. It is thought that the morphological data throw light on the pathogenesis and pathophysiology of anthrax but also demonstrate a common mechanism of tissue injury and death caused by many bacteria. 91 monkeys were exposed for up to 32 days to dusty air from a mill processing imported goat hair known to contain anthrax spores. 23 monkeys contracted inhalation anthrax. The morphologic study of the infected monkeys supported the notion that in most cases of inhalation anthrax, spores are carried to the mediastinal lymph nodes where they germinate and produce a primary lymphatic infection. The large bacteria quickly invade the bloodstream and cause fatal septicaemia. The anthrax bacillus produces a toxin which often causes marked local vascular injury with oedema, haemorrhage and thrombosis. In anthrax septicaemia the toxin causes generalised vascular injury with widespread capillary thrombosis, circulatory failure, shock, and death.
Descriptors (primary) anthrax; wool industry; respirable dust; respiratory diseases
Descriptors (secondary) spores; lymph nodes; hair, bristles; tissue damage; animal experiments; cardiovascular diseases; bacteraemia, septicaemia
Document type D - Periodical articles
Subject(s) Textile and clothing industries
Broad subject area(s) Biological hazards
Browse category(ies) Bacterial and parasitic diseases
Diseases of the respiratory system (except for pneumoconiosis & similar)