|Document ID (ISN)||19655|
|ISSN - Serial title
||0363-0153 - Archives of Pathology
|Convention or series no.
||Dalldorf F.G., Kaufmann A.F., Brachman P.S.
||Woolsorters' disease - An experimental model
||Dec. 1971, Vol.92, p.418-426. Illus. 27 ref.
||Description of an experimental model of inhalation anthrax in monkeys that very closely mimics woolsorters' disease. It is thought that the morphological data throw light on the pathogenesis and pathophysiology of anthrax but also demonstrate a common mechanism of tissue injury and death caused by many bacteria. 91 monkeys were exposed for up to 32 days to dusty air from a mill processing imported goat hair known to contain anthrax spores. 23 monkeys contracted inhalation anthrax. The morphologic study of the infected monkeys supported the notion that in most cases of inhalation anthrax, spores are carried to the mediastinal lymph nodes where they germinate and produce a primary lymphatic infection. The large bacteria quickly invade the bloodstream and cause fatal septicaemia. The anthrax bacillus produces a toxin which often causes marked local vascular injury with oedema, haemorrhage and thrombosis. In anthrax septicaemia the toxin causes generalised vascular injury with widespread capillary thrombosis, circulatory failure, shock, and death.
||anthrax; wool industry; respirable dust; respiratory diseases
||spores; lymph nodes; hair, bristles; tissue damage; animal experiments; cardiovascular diseases; bacteraemia, septicaemia
||D - Periodical articles
||Textile and clothing industries
|Broad subject area(s)
||Bacterial and parasitic diseases
Diseases of the respiratory system (except for pneumoconiosis & similar)