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CISDOC database

Document ID (ISN)19647
CIS number 72-2477
ISSN - Serial title 0032-6291 - PracovnÝ lÚkařstvÝ
Year 1972
Convention or series no.
Author(s) CramÚr K., Selander S.
Title Comparison between D-penicillamine and N-acetyl-D-penicillamine in the treatment of lead poisoning
Bibliographic information Mar. 1972, Vol.24, No.2-3, p.46-48. Illus. 7 ref.
Abstract D-Penicillamine and N-acetyl-D-penicillamine were compared in the treatment of 2 workers with excessive lead absorption. The acetylated compound did not produce any significant increase in urinary lead; the non-acetylated compound had a satisfactory chelating action and produced an immediate reduction in urinary concentration and 24-h elimination of δ-aminolevulinic acid. The existence of a free amino group is essential for the chelating of D-penicillamine.
Descriptors (primary) lead; chelation therapy; chronic poisoning; toxicology
Descriptors (secondary) ALAD; urinary ala monitoring; shipbreaking; penicillamine
Document type D - Periodical articles
Subject(s) Medicine, hygiene and first aid
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Lead and compounds