ILO Home
Go to the home page
Site map | Contact us Français | Espańol

CISDOC database

Document ID (ISN)19318
CIS number 73-220
ISSN - Serial title 0032-6291 - Pracovní lékařství
Year 1972
Convention or series no.
Author(s) Krampl V.
Title The value of enzyme activity changes in assessing chlorinated cyclodiene pesticide toxicity
Original title Dynamika zmien enzýmovej aktivity pri hodnotení toxicity pesticídov na báze chlórovaných cyklodienových zlúčenín [in Czech]
Bibliographic information Jan. 1972, Vol.24, No.1, p.3-7. 18 ref.
Abstract Dieldrin and aldrin in an oil solution were administered per os, at a rate of 7 and 12mg/kg body weight per day for 4 weeks, to 2 groups of rats and at a rate of 40mg/kg (2/3 of the LD50) in a single dose to a third group. In each case there was an increase in glutamic pyruvic transaminase and serum aldolase. Maximum activity was observed 72h following administration of the single dose and the 7th day following administration of repeated doses. After 28 days, enzyme activity had returned to normal. On the basis of these results, the author considers that glutamic pyruvic transaminase and serum aldolase activity may be employed as a useful criterion for evaluating the acute and sub-acute toxicity of the substances in question.
Descriptors (primary) enzyme disturbances; pesticides; chlorinated hydrocarbons; toxic substances; toxicology
Descriptors (secondary) serum; aldrin; animal experiments; aldolase; glutamic-pyruvic transaminase; dieldrin
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Halogenated hydrocarbons