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Document ID (ISN)18744
CIS number 73-1379
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1972
Convention or series no.
Author(s) Mullin L.S.
Title Halogenated hydrocarbon-induced cardiac arrhythmias associated with release of endogenous epinephrine
Bibliographic information June 1972, Vol.33, No.6, p.389-396. Illus. 23 ref.
Abstract Certain unsubstituted and halogenated hydrocarbons are known to release endogenous epinephrine and to cause cardiac sensitisation. Experiments were carried out on exercising dogs exposed to known concentrations of flurocarbons 11, 12 and 114; exercise was chosen as a means of increasing the production of epinephrine to a level where cardiac sensitisation could occur. It was found that, whereas fluorocarbons 12 and 114 did produce cardiac sensitisation, a much higher concentration was needed to produce this effect than with intravenous epinephrine administration. Fluorocarbon 11 did not produce the same effect at the test concentrations chosen.
Descriptors (primary) mixed halogenated hydrocarbons; biological hazards; epinephrine excretion; arrhythmia
Descriptors (secondary) dichlorotetrafluoroethane; dichlorodifluoromethane; trichlorofluoromethane; functional heart disorders; exposure; adrenal gland disorders; animal experiments; biological effects; inhalation
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Cardiovascular diseases
Halogenated hydrocarbons
Biological hazards