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CISDOC database

Document ID (ISN)112440
CIS number 12-0239
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Zhang L., Ye F.L., Chen T., Mei Y., Song S.Z.
Title Trans, trans-muconic acid as a biomarker of occupational exposure to high-level benzene in China
Bibliographic information Oct. 2011, Vol.53, No.10, p.1194-1198. Illus. 41 ref.
Internet access Trans_trans-muconic_acid_[BUY_THIS_ARTICLE] [in English]
Abstract The work aimed to study the potential correlation between high-level benzene exposures and urinary benzene metabolites S-phenylmercapturic acid (SPMA) and trans, trans-muconic acid (t,t-MA) among Chinese shoe industry workers. Individual benzene-exposed levels were determined by gas chromatography analysis; urinary metabolites were determined by high performance liquid chromatography coupled with mass spectrometry. The concentration of benzene ranged from 2.57 to 146.11 mg/m3. The correlation between benzene and t,t-MA was significantly higher than that of SPMA at the postshift. It is concluded that t,t-MA is a more specific biomarker than SPMA at high-level benzene exposures.
Descriptors (primary) China; benzene; trans,trans-muconic acid; exposure tests; shoe industry
Descriptors (secondary) determination in urine; exposure evaluation; reliability; description of technique
Document type D - Periodical articles
Subject(s) Leather, fur and footwear
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic hydrocarbons
Exposure evaluation
Footwear, leather and fur industry