|Document ID (ISN)||112435|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Cave M., Falkner K.C., Henry L., Costello B., Gregory B., McClain C.J
||Serum cytokeratin 18 and cytokine elevations suggest a high prevalence of occupational liver disease in highly exposed elastomer/polymer workers
||Oct. 2011, Vol.53, No.10, p.1128-1133. 42 ref.
||Serum_cytokeratin_18_[BUY_THIS_ARTICLE] [in English]
ILO_LABORDOC_[INTRANET_ACCESS] [in English]
||Cytokeratin 18 (CK18) is a novel serologic biomarker for occupational liver disease. The purpose of this study was to determine the prevalence of CK18 elevation in elastomer/polymer workers exposed to acrylonitrile, 1,3-butadiene, and styrene. A total of 82 chemical workers were evaluated. Cytokeratin 18 was determined by enzyme-linked immunosorbent assay and proinflammatory cytokines were measured by multi-analyte chemiluminescent detection. Thirty-nine percent (32 of 82) had elevated CK18 levels. The pattern of CK18 elevation was consistent with toxicant-associated steatohepatitis (TASH) in the majority of cases (78%). Tumor necrosis factor α, interleukin-6, interleukin-8, monocyte chemotactic protein-1, and plasminogen activator inhibitor-1 were increased in these workers compared with those with normal CK18 levels. These results suggest a high prevalence of occupational liver disease and TASH in elastomer/polymer workers with elevated proinflammatory cytokines.
||ABS; toxic substances; hepatic diseases; exposure tests; chemical industry; risk factors
||butadiene; styrene; acrylonitrile; interleukins; determination in blood; immunology
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology