Document ID (ISN) | 112413 |
CIS number |
12-0170 |
ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
Year |
2011 |
Convention or series no. |
|
Author(s) |
Gambelunghe A., Buratta S., Ferrara G., Mozzi R., Marchetti C., Murgia N., Muzi G. |
Title |
Phosphatidylserine metabolism in human lymphoblastic cells exposed to chromium (IV) |
Bibliographic information |
July 2011, Vol.53, No.7, p.776-781. Illus. 27 ref. |
Internet access |
Phosphatidylserine_metabolism_[BUY_THIS_ARTICLE] [in English]
ILO_LABORDOC_[INTRANET_ACCESS] [in English]
|
Abstract |
Hexavalent chromium compounds are widely found in working environments. These compounds can cause apoptosis in human cells, but the mechanisms underlying chromium-induced apoptosis are not clear. A marker of apoptosis is the exposure of phosphatidylserine on cell membrane and the modification of phosphatidylserine metabolism. The aim of this study was to verify whether chromium could cause phosphatidylserine exposure and modification of its metabolism in human lymphoblastic leukemia cell line (MOLT-4). Phosphatidylserine exposure was evaluated by annexin V binding whereas phosphatidylserine metabolism was studied measuring the incorporation of [3H]serine. Cell treatment with hexavalent chromium increases phosphatidylserine exposure and cell apoptosis, but decreases the incorporation of [3H]serine into phosphatidylserine in a dose- and time-dependent manner. |
Descriptors (primary) |
chromium and compounds; leukaemia; lymphocytes; metabolic studies |
Descriptors (secondary) |
radioactive substances; cell culture; immunology; in vitro experiments; dose-response relationship |
Document type |
D - Periodical articles |
Subject(s) |
Toxic and dangerous substances Occupational pathology
|
Broad subject area(s) |
Occupational medicine, epidemiology Chemical safety
|
Browse category(ies) |
Toxicology
|