| Document ID (ISN) | 112315 |
| CIS number |
12-0133 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
2011 |
| Convention or series no. |
|
| Author(s) |
Van Dyke M.V., Martyny J.W., Mroz M.M., Silveira L.J., Strand M., Cragle D.L., Tankersley W.G., Wells S.M., Newman L.S., Maier L.A. |
| Title |
Exposure and genetics increase risk of beryllium sensitization and chronic beryllium disease in the nuclear weapons industry |
| Bibliographic information |
Nov. 2011, Vol.68, No.11, p.842-848. 39 ref. |
| Internet access |
Exposure_and_genetics_increase_risk_[INTERNET_FREE_ACCESS] [in English]
|
| Abstract |
Beryllium sensitisation (BeS) and chronic beryllium disease (CBD) are caused by exposure to beryllium with susceptibility affected by at least one well-studied genetic host factor, a glutamic acid residue at position 69 (E69) of the HLA-DPß chain (DPßE69). The goal of this study was to determine the relationship between DPßE69 and exposure in BeS and CBD. 181 current and former workers from a nuclear weapons production facility were enrolled in a case-control study including 35 individuals with BeS and 19 with CBD. HLA-DPB1 genotypes were determined by PCR-SSP. Beryllium exposures were assessed through worker interviews and industrial hygiene assessment of work tasks. Multivariate models showed a sixfold (odds ratio (OR) 6.06) increased odds for BeS and CBD combined among DPßE69 carriers and a fourfold (OR 3.98) increased odds for those exposed over an assigned lifetime-weighted average exposure of 0.1 ¿g/m3. Those with both risk factors had higher increased odds (OR 24.1). DPßE69 carriage and high exposure to beryllium appear to contribute individually to the development of BeS and CBD. Among workers at a beryllium-using facility, the magnitude of risk associated with either elevated beryllium exposure or carriage of DPßE69 alone appears to be similar. |
| Descriptors (primary) |
USA; beryllium; sensitization; berylliosis; individual susceptibility; armaments industry; risk factors |
| Descriptors (secondary) |
exposure evaluation; statistical evaluation; genetic effects |
| Document type |
D - Periodical articles |
| Subject(s) |
Metal production and metalworking
Toxic and dangerous substances
Occupational pathology
|
| Broad subject area(s) |
Occupational medicine, epidemiology
Chemical safety
|
| Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar)
Metalworking industry
|
