|Document ID (ISN)||112315|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Van Dyke M.V., Martyny J.W., Mroz M.M., Silveira L.J., Strand M., Cragle D.L., Tankersley W.G., Wells S.M., Newman L.S., Maier L.A.
||Exposure and genetics increase risk of beryllium sensitization and chronic beryllium disease in the nuclear weapons industry
||Nov. 2011, Vol.68, No.11, p.842-848. 39 ref.
||Exposure_and_genetics_increase_risk_[INTERNET_FREE_ACCESS] [in English]
||Beryllium sensitisation (BeS) and chronic beryllium disease (CBD) are caused by exposure to beryllium with susceptibility affected by at least one well-studied genetic host factor, a glutamic acid residue at position 69 (E69) of the HLA-DP▀ chain (DP▀E69). The goal of this study was to determine the relationship between DP▀E69 and exposure in BeS and CBD. 181 current and former workers from a nuclear weapons production facility were enrolled in a case-control study including 35 individuals with BeS and 19 with CBD. HLA-DPB1 genotypes were determined by PCR-SSP. Beryllium exposures were assessed through worker interviews and industrial hygiene assessment of work tasks. Multivariate models showed a sixfold (odds ratio (OR) 6.06) increased odds for BeS and CBD combined among DP▀E69 carriers and a fourfold (OR 3.98) increased odds for those exposed over an assigned lifetime-weighted average exposure of 0.1 ┐g/m3. Those with both risk factors had higher increased odds (OR 24.1). DP▀E69 carriage and high exposure to beryllium appear to contribute individually to the development of BeS and CBD. Among workers at a beryllium-using facility, the magnitude of risk associated with either elevated beryllium exposure or carriage of DP▀E69 alone appears to be similar.
||USA; beryllium; sensitization; berylliosis; individual susceptibility; armaments industry; risk factors
||exposure evaluation; statistical evaluation; genetic effects
||D - Periodical articles
||Metal production and metalworking
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
||Diseases of the respiratory system (except for pneumoconiosis & similar)