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Document ID (ISN)112315
CIS number 12-0133
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Van Dyke M.V., Martyny J.W., Mroz M.M., Silveira L.J., Strand M., Cragle D.L., Tankersley W.G., Wells S.M., Newman L.S., Maier L.A.
Title Exposure and genetics increase risk of beryllium sensitization and chronic beryllium disease in the nuclear weapons industry
Bibliographic information Nov. 2011, Vol.68, No.11, p.842-848. 39 ref.
Internet access Exposure_and_genetics_increase_risk_[INTERNET_FREE_ACCESS] [in English]
Abstract Beryllium sensitisation (BeS) and chronic beryllium disease (CBD) are caused by exposure to beryllium with susceptibility affected by at least one well-studied genetic host factor, a glutamic acid residue at position 69 (E69) of the HLA-DP▀ chain (DP▀E69). The goal of this study was to determine the relationship between DP▀E69 and exposure in BeS and CBD. 181 current and former workers from a nuclear weapons production facility were enrolled in a case-control study including 35 individuals with BeS and 19 with CBD. HLA-DPB1 genotypes were determined by PCR-SSP. Beryllium exposures were assessed through worker interviews and industrial hygiene assessment of work tasks. Multivariate models showed a sixfold (odds ratio (OR) 6.06) increased odds for BeS and CBD combined among DP▀E69 carriers and a fourfold (OR 3.98) increased odds for those exposed over an assigned lifetime-weighted average exposure of 0.1 ┐g/m3. Those with both risk factors had higher increased odds (OR 24.1). DP▀E69 carriage and high exposure to beryllium appear to contribute individually to the development of BeS and CBD. Among workers at a beryllium-using facility, the magnitude of risk associated with either elevated beryllium exposure or carriage of DP▀E69 alone appears to be similar.
Descriptors (primary) USA; beryllium; sensitization; berylliosis; individual susceptibility; armaments industry; risk factors
Descriptors (secondary) exposure evaluation; statistical evaluation; genetic effects
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Metalworking industry