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CISDOC database

Document ID (ISN)112307
CIS number 12-0128
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Lee M.S., Magari S., Christiani D.C.
Title Cardiac autonomic dysfunction from occupational exposure to polycyclic aromatic hydrocarbons
Bibliographic information July 2011, Vol.68, No.7, p.474-478. Illus. 40 ref.
Internet access Cardiac_autonomic_dysfunction_[BUY_THIS_ARTICLE] [in English]
Abstract Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiopulmonary mortality and cardiovascular events. This study investigated the association between a biological marker of PAH exposure, assessed by urinary 1-hydroxypyrene (1-OHP), and heart-rate variability in an occupational cohort of boilermakers. Continuous 24 h monitoring of the ambulatory electrocardiogram (ECG) and pre- and postshift urinary 1-OHP were repeated over extended periods of the work week. Data were subjected to statistical analyses. Findings provide evidence that occupational exposure to PAHs is associated with altered cardiac autonomic function. Acute exposure to PAHs may be an important predictor of cardiovascular disease risk in the work environment.
Descriptors (primary) aromatic hydrocarbons; polycyclic hydrocarbons; cardiovascular diseases; exposure evaluation; boilermaking; risk factors
Descriptors (secondary) 1-hydroxypyrene; determination in urine; electrocardiography; heart rate monitoring; cohort study; statistical evaluation
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Metal production and metalworking
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Aromatic hydrocarbons
Polycyclic hydrocarbons
Cardiovascular diseases
Metalworking industry