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Document ID (ISN)112299
CIS number 12-0122
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2011
Convention or series no.
Author(s) Wang T., Jia G., Zhang J., Ma Y., Feng W., Liu L., Zhang N., Yan L., Wang X., Zhang X., Liu Z., Du X., Zhen S.
Title Renal impairment caused by chronic occupational chromate exposure
Bibliographic information Apr. 2011, Vol.84, No.4, p.393-401. Illus. 52 ref.
Internet access Renal_impairment_[INTERNET_FREE_ACCESS] [in English]
Abstract The objective of this study was to determine the nephritic toxicity of chromate after chronic occupational exposure. The environmental contamination was assessed by measuring the chromium (Cr) in 8-h airborne sampler. The integrated level of Cr was determined by Cr concentrations in the whole blood (WB-Cr) and the urine (U-Cr). The renal glomerular and tubule impairment was evaluated by determination of cystatin C (Cys-C) in the serum and microalbumin (mALB), urinary beta(2)-microglobulin (▀(2)M), N-acetyl-beta-D-glucosaminidase (NAG) activity in the urine. The mean occupational exposure time to Cr was 12.86 years with average daily air level of 27.13 ┐g/m3 comparing to 0.11 ┐g/m3 of the background level. The WB-Cr and U-Cr were 23.49 ┐g/L and 17.41 ┐g/g creatinine (Cre), respectively in the chromate-exposed workers comparing to 3.32 ┐g/L and 1.52 ┐g/g Cre in the controls. The serum Cys-C and urinary mALB were significantly increased in the chromate-exposed workers. Exposure to Cr seems to induce an enhanced level of urinary NAG activity and ▀(2)M concentration. The increased serum Cys-C concentration was positively correlated with the level of serum Cre. The U-Cr was positively correlated to the concentrations of urinary mALB, ▀(2)M, and the activity of NAG. It is concluded that chronic occupational exposure to chromate causes comprehensive renal impairment though more severity could occur in the tubule than in the glomerular function.
Descriptors (primary) chromates; renal damage; exposure tests; nephrotoxic effects; risk factors
Descriptors (secondary) China; breathing atmosphere; determination in blood; determination in urine; case-control study
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Diseases of the kidney and the urinary system