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Document ID (ISN)112281
CIS number 12-0036
ISBN(s) 978-3-7776-1477-9
Year 2006
Convention or series no. BUA Report 254
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA)
Title N,N-bis(2,2,6,6-Tetramethylpiperidine-4-yl)hexane-1,6-diamine
Bibliographic information Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiii, 35p. Bibl.ref. Price: EUR 36.00.
Internet access BUA_Report_254_Summary_[INTERNET_FREE_ACCESS] [in English]
BUA_Report_254_[BUY_THIS_DOCUMENT].pdf [in English]
Abstract Conclusions of this criteria document which reflects the state of knowledge as of November 2004: no studies are available on the mechanism of action or toxicokinetics of hexamethylene-bis-triacetone diamine (HMBTAD, common name of N,N-bis(2,2,6,6-tetramethylpiperidine-4-yl)hexane-1,6-diamine). The oral LD50 of HMBTAD in rats is between 820 and 880 mg/kg. Symptoms of poisoning are disturbed coordination, a decrease in triggered reflexes, jerking, light to heavy sedation and ataxia, tremor, a squatting position and hypothermia. Beginning at a concentration of 1000 mg HMBTAD/kg, paralysis of hind legs, ptosis and cyanosis were also observed. All treated animals had hyperaemia of the gastric and intestinal mucous membranes. HMBTAD is corrosive to the skin and eyes of rabbits. It is not sensitizing in guinea pigs. In the mutagenicity test on Salmonella typhimurium and the HPRT gene mutation test with V79 cells, HMBTAD is not mutagenic at concentrations up to 5000 µg/plate. HMBTAD is not clastogenic in the chromosome aberration test with human peripheral lymphocytes. Studies on the carcinogenic potential of HMBTAD are not available. Available in vitro genotoxicity studies give negative results. Other findings are discussed.
Descriptors (primary) Germany; pyridine and derivatives; toxicology; ecotoxicology
Descriptors (secondary) animal experiments; in vitro experiments; literature survey; criteria document
Document type B - Chemical safety information sheets
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Toxicology
Heterocyclic compounds