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CISDOC database
| Document ID (ISN) | 112280 |
| CIS number |
12-0035 |
| ISBN(s) |
978-3-7776-1479-3 |
| Year |
2006 |
| Convention or series no. |
BUA Report 255
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| Author(s) |
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA) |
| Title |
2,2,6,6-Tetramethyl-4-piperidone |
| Bibliographic information |
Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiii, 43p. Bibl.ref. Price: EUR 47.00. |
| Internet access |
BUA_Report_255_Summary_[INTERNET_FREE_ACCESS] [in English]
BUA_Report_255_[BUY_THIS_DOCUMENT].pdf [in English]
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| Abstract |
Conclusions of this criteria document which reflects the state of knowledge as of November 2004: Studies are lacking on the toxicokinetics of triacetonamine (common name of 2,2,6,6-tetramethyl-4-piperidone) and the acute toxicity after inhalational uptake. The LD50 of triacetonamine in rats is between 1000 and 2000 mg/kg after oral uptake and higher than 2000 mg/kg after dermal uptake. Acute signs of poisoning are a rough coat, timidity, reduced movement, slight tremor, staggering, ataxia, cardiac dysrhythmia, a drop in blood pressure, breathing difficulty, hypothermia and a prone position. Validated investigations with repeated administration of triacetonamine are not available. Triacetonamine is corrosive to the skin and eyes of rabbits. In the maximization test, triacetonamine is sensitizing to guinea pigs. Triacetonamine is negative in the mutagenicity test with Salmonella typhimurium or Escherichia coli. Studies on the carcinogenic potential of triacetonamine are not available. In vitro genotoxicity investigations with bacteria gave negative results No studies exist on the genotoxicity in vivo. Other findings are discussed. |
| Descriptors (primary) |
Germany; 4-oxo-2,2,6,6-tetramethylpiperidine; toxicology; ecotoxicology |
| Descriptors (secondary) |
irritants; sensitizers; animal experiments; in vitro experiments; literature survey; criteria document |
| Document type |
B - Chemical safety information sheets |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Toxicology
Ketones
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