|Document ID (ISN)||112279|
|Convention or series no.
||BUA Report 250
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA)
||Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xv, 77p. Bibl.ref. Price: EUR 54.00.
||BUA_Report_250_Summary_[INTERNET_FREE_ACCESS] [in English]
BUA_Report_250_[BUY_THIS_DOCUMENT].pdf [in English]
||Conclusions of this criteria document which reflects the state of knowledge as of February 2004: The toxicity of 4-methoxybenzaldehyde after oral administration is weak. The lowest LD50 in the rat and guinea pig are 1510 mg/kg and 1260 mg/kg, respectively. Dermal LD50 values reported in rabbits and guinea pigs are 5000 mg/kg and 11200 mg/kg, respectively. In humans, a 48h administration of a 20% solution to the skin of the back causes no irritation. 10% solutions are neither irritant nor sensitizing. It is not mutagenic in the mutagenicity tests with Salmonella typhimurium or Escherichia coli. 4-Methoxybenzaldehyde showed no tumour-promoting effect in an initiation-promotion experiment with the endpoint skin papillomas. Other findings are discussed.
||Germany; aromatic aldehydes; toxicology; ecotoxicology
||animal experiments; literature survey; criteria document
||B - Chemical safety information sheets
||Toxic and dangerous substances
|Broad subject area(s)