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Document ID (ISN)112279
CIS number 12-0034
ISBN(s) 978-3-7776-1473-1
Year 2006
Convention or series no. BUA Report 250
Author(s)
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA)
Title 4-Methoxybenzaldehyde
Bibliographic information Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xv, 77p. Bibl.ref. Price: EUR 54.00.
Internet access BUA_Report_250_Summary_[INTERNET_FREE_ACCESS] [in English]
BUA_Report_250_[BUY_THIS_DOCUMENT].pdf [in English]
Abstract Conclusions of this criteria document which reflects the state of knowledge as of February 2004: The toxicity of 4-methoxybenzaldehyde after oral administration is weak. The lowest LD50 in the rat and guinea pig are 1510 mg/kg and 1260 mg/kg, respectively. Dermal LD50 values reported in rabbits and guinea pigs are 5000 mg/kg and 11200 mg/kg, respectively. In humans, a 48h administration of a 20% solution to the skin of the back causes no irritation. 10% solutions are neither irritant nor sensitizing. It is not mutagenic in the mutagenicity tests with Salmonella typhimurium or Escherichia coli. 4-Methoxybenzaldehyde showed no tumour-promoting effect in an initiation-promotion experiment with the endpoint skin papillomas. Other findings are discussed.
Descriptors (primary) Germany; aromatic aldehydes; toxicology; ecotoxicology
Descriptors (secondary) animal experiments; literature survey; criteria document
Document type B - Chemical safety information sheets
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aldehydes
Toxicology