|Document ID (ISN)||112226|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Madrigano J., Baccarelli A., Wright R.O., Suh H., Sparrow D., Vokonas P.S., Schwartz J.
||Air pollution, obesity, genes and cellular adhesion molecules
||May 2010, Vol.67, No.5, p.312-317. Illus. 37 ref.
||Air_pollution.pdf [in English]
||This study examined the association between particulate matter and cell adhesion molecules, together with the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association. Mixed regression models were used to examine the association of PM2.5 and black carbon with serum concentrations of soluble intercellular adhesion molecule (sICAM-1) and soluble vascular cell adhesion molecule (sVCAM-1), markers of endothelial function and inflammation, in a longitudinal study of 809 participants in the Normative Ageing Study (1819 total observations). Whether this association was modified by genotype, obesity or diabetes status was also examined. Genes selected for analyses were related to oxidative stress, endothelial function, lipid metabolism or metal processing. Black carbon during the two days prior to blood draw was significantly associated with increased sVCAM-1 (4.5% increase per 1 μg/m3). Neither pollutant was associated with sICAM-1. Larger effects of black carbon on sVCAM were seen in subjects with obesity and who were GSTM1 null. It is concluded that black carbon is associated with markers of endothelial function and inflammation. Genes related to oxidative defence may modify this association.
||atmospheric pollution; particle size; carbon black; genetic effects; risk factors
||proteins; obesity; diabetes mellitus; determination in blood; statistical evaluation; individual susceptibility
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology