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CISDOC database

Document ID (ISN)112226
CIS number 11-0812
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Madrigano J., Baccarelli A., Wright R.O., Suh H., Sparrow D., Vokonas P.S., Schwartz J.
Title Air pollution, obesity, genes and cellular adhesion molecules
Bibliographic information May 2010, Vol.67, No.5, p.312-317. Illus. 37 ref.
Internet access Air_pollution.pdf [in English]
Abstract This study examined the association between particulate matter and cell adhesion molecules, together with the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association. Mixed regression models were used to examine the association of PM2.5 and black carbon with serum concentrations of soluble intercellular adhesion molecule (sICAM-1) and soluble vascular cell adhesion molecule (sVCAM-1), markers of endothelial function and inflammation, in a longitudinal study of 809 participants in the Normative Ageing Study (1819 total observations). Whether this association was modified by genotype, obesity or diabetes status was also examined. Genes selected for analyses were related to oxidative stress, endothelial function, lipid metabolism or metal processing. Black carbon during the two days prior to blood draw was significantly associated with increased sVCAM-1 (4.5% increase per 1 μg/m3). Neither pollutant was associated with sICAM-1. Larger effects of black carbon on sVCAM were seen in subjects with obesity and who were GSTM1 null. It is concluded that black carbon is associated with markers of endothelial function and inflammation. Genes related to oxidative defence may modify this association.
Descriptors (primary) atmospheric pollution; particle size; carbon black; genetic effects; risk factors
Descriptors (secondary) proteins; obesity; diabetes mellitus; determination in blood; statistical evaluation; individual susceptibility
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Exposure evaluation
Risk evaluation
Air pollution