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Document ID (ISN)112214
CIS number 11-0900
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2010
Convention or series no.
Author(s) Karvala K., Toskala E., Luukkonen R., Lappalainen S., Uitti J., Nordman H.
Title New-onset adult asthma in relation to damp and moldy workplaces
Bibliographic information Dec. 2010, Vol.83, No.8, p.855-865. Illus. 43 ref.
Internet access New-onset_adult_asthma.pdf [in English]
Abstract Damp and mouldy indoor environments aggravate pre-existing asthma. Recent meta-analyses suggest that exposure to such environments may also induce new-onset asthma. This study assessed the probability of moulds being the cause of asthma in a series of 694 patients examined between 1995 and 2004.because of respiratory symptoms in relation to workplace dampness and moulds. According to their histories, they had all been exposed to moulds at work and had suffered from work-related lower respiratory symptoms. The investigations had included specific inhalation challenge (SIC) tests with mould extracts and serial peak expiratory flow (PEF) recordings. The patients were categorized into three groups: probable, possible, and unlikely occupational asthma (OA, 156, 45, and 475 patients, respectively). The clinical details of 258 patients were analyzed, and their levels of microbial exposure were evaluated. The agreement between the serial PEF recordings and SIC tests was 56%. In the group of probable OA, mould sensitization was found in 20%. The level of exposure and sensitization to moulds was associated with probable OA. At six months, the follow-up examinations of 136 patients with probable OA showed that the symptoms were persistent, and no improvement in spirometry was noted despite adequate treatment. Only 58% of the patients had returned to work. It is concluded that exposure to damp and mouldy workplaces can induce new-onset adult asthma.
Descriptors (primary) humidity; moulds; premises and workplaces; sensitization; asthma; risk factors
Descriptors (secondary) Finland; symptoms; spirometry; exposure evaluation; subjective assessment; statistical evaluation; medical examinations
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Biological hazards
General safety, health and conditions of work
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Biological hazards