|Document ID (ISN)||112212|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Nassar N., Abeywardana P., Barker A., Bower C.
||Parental occupational exposure to potential endocrine disrupting chemicals and risk of hypospadias in infants
||Sep. 2010, Vol.67, No.9, p.585-589. 37 ref.
||The aim of this study was to investigate the association between both maternal and paternal occupational exposures to endocrine disrupting chemicals (EDCs) and hypospadias. This registry-based case-control study considered 1202 cases of hypospadias in children born in Western Australia between 1980 and 2000 and 2583 male controls randomly selected from birth records for whom information regarding parental occupation was available. Occupational exposures to seven groups of potential EDCs were independently coded by two researchers according to a validated job-exposure matrix. Multivariable analysis showed a strong association with potential maternal occupational exposure to heavy metals with an over twofold increased risk of hypospadias (odds ratio OR 2.6), and women exposed to phthalates were more likely to have an affected son (OR 1.2). Compared with mild or isolated cases, the risks of moderate-severe hypospadias or multiple defects were increased up to two- and fivefold, respectively, with maternal exposure to most types of EDCs. Paternal occupational exposures to polychlorinated organic compounds (OR 1.3) and bi-phenolic compounds (OR 1.6) were also possible risk factors.
||genito-urinary system diseases; children; parental exposure; job-exposure relation; endocrine effects; risk factors
||Western Australia; metals; aromatic diols; phthalates; chlorinated organic compounds; case-control study; statistical evaluation; women
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology