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CISDOC database

Document ID (ISN)112212
CIS number 11-0809
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Nassar N., Abeywardana P., Barker A., Bower C.
Title Parental occupational exposure to potential endocrine disrupting chemicals and risk of hypospadias in infants
Bibliographic information Sep. 2010, Vol.67, No.9, p.585-589. 37 ref.
Abstract The aim of this study was to investigate the association between both maternal and paternal occupational exposures to endocrine disrupting chemicals (EDCs) and hypospadias. This registry-based case-control study considered 1202 cases of hypospadias in children born in Western Australia between 1980 and 2000 and 2583 male controls randomly selected from birth records for whom information regarding parental occupation was available. Occupational exposures to seven groups of potential EDCs were independently coded by two researchers according to a validated job-exposure matrix. Multivariable analysis showed a strong association with potential maternal occupational exposure to heavy metals with an over twofold increased risk of hypospadias (odds ratio OR 2.6), and women exposed to phthalates were more likely to have an affected son (OR 1.2). Compared with mild or isolated cases, the risks of moderate-severe hypospadias or multiple defects were increased up to two- and fivefold, respectively, with maternal exposure to most types of EDCs. Paternal occupational exposures to polychlorinated organic compounds (OR 1.3) and bi-phenolic compounds (OR 1.6) were also possible risk factors.
Descriptors (primary) genito-urinary system diseases; children; parental exposure; job-exposure relation; endocrine effects; risk factors
Descriptors (secondary) Western Australia; metals; aromatic diols; phthalates; chlorinated organic compounds; case-control study; statistical evaluation; women
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Endocrine diseases
Risk evaluation