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CISDOC database

Document ID (ISN)112145
CIS number 11-0830
ISSN - Serial title 1545-9624 - Journal of Occupational and Environmental Hygiene
Year 2010
Convention or series no.
Author(s) Martin A., Bois F.Y., Pierre F., Wild P.
Title Occupational exposure to cobalt: A population toxicokinetic modeling approach validated by field results challenges the biological exposure index for urinary cobalt
Bibliographic information Jan. 2010, Vol.7, No.1, p.54-62. Illus. 22 ref.
Internet access Occupational_exposure_to_cobalt.pdf [in English]
Abstract This study modelled the urinary toxicokinetics of cobalt exposure based on 507 urine samples from 16 workers, followed up for one week, and 108 related atmospheric cobalt measurements to determine an optimal urinary cobalt sampling strategy at work and a corresponding urinary exposure threshold (UET). These data were used to calibrate a population toxicokinetic model, taking into account both the measurement uncertainty and intra- and inter-individual variability. Using the calibrated model, urinary sampling sensitivity and specificity performance in detecting exposure above the 20 μg/m3 threshold limit value, time-weighted average (TLV-TWA), was applied to identify an optimal urine sampling time. Total atmospheric cobalt concentrations were found to be in the 5-144 μg/m3 range, and total urinary cobalt concentrations are 0.5-88 μg/g creatinine. A two-compartment toxicokinetic model which best describes urinary elimination is presented.
Descriptors (primary) cobalt and compounds; urinary excretion; sampling and analysis; determination in urine; exposure tests
Descriptors (secondary) determination in air; exposure evaluation; reliability; threshold limit values; description of technique
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring