Document ID (ISN) | 112145 |
CIS number |
11-0830 |
ISSN - Serial title |
1545-9624 - Journal of Occupational and Environmental Hygiene |
Year |
2010 |
Convention or series no. |
|
Author(s) |
Martin A., Bois F.Y., Pierre F., Wild P. |
Title |
Occupational exposure to cobalt: A population toxicokinetic modeling approach validated by field results challenges the biological exposure index for urinary cobalt |
Bibliographic information |
Jan. 2010, Vol.7, No.1, p.54-62. Illus. 22 ref. |
Internet access |
Occupational_exposure_to_cobalt.pdf [in English]
|
Abstract |
This study modelled the urinary toxicokinetics of cobalt exposure based on 507 urine samples from 16 workers, followed up for one week, and 108 related atmospheric cobalt measurements to determine an optimal urinary cobalt sampling strategy at work and a corresponding urinary exposure threshold (UET). These data were used to calibrate a population toxicokinetic model, taking into account both the measurement uncertainty and intra- and inter-individual variability. Using the calibrated model, urinary sampling sensitivity and specificity performance in detecting exposure above the 20 μg/m3 threshold limit value, time-weighted average (TLV-TWA), was applied to identify an optimal urine sampling time. Total atmospheric cobalt concentrations were found to be in the 5-144 μg/m3 range, and total urinary cobalt concentrations are 0.5-88 μg/g creatinine. A two-compartment toxicokinetic model which best describes urinary elimination is presented. |
Descriptors (primary) |
cobalt and compounds; urinary excretion; sampling and analysis; determination in urine; exposure tests |
Descriptors (secondary) |
determination in air; exposure evaluation; reliability; threshold limit values; description of technique |
Document type |
D - Periodical articles |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Biological monitoring
|