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CISDOC database
Document ID (ISN) | 112086 |
CIS number |
11-0675 |
ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
Year |
2011 |
Convention or series no. |
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Author(s) |
Boffetta P., Fontana L., Stewart P., Zaridze D., Szeszenia-Dabrowska N., Janout V., Bencko V., Foretova L., Jinga V., Matveev V., Kollarova H., Ferro G., Chow W.H., Rothman N., van Bemmel D., Karami S., Brennan P., Moore L.E. |
Title |
Occupational exposure to arsenic, cadmium, chromium, lead and nickel, and renal cell carcinoma: A case-control study from Central and Eastern Europe |
Bibliographic information |
Oct. 2011, Vol.68, No.10, p.723-728. 37 ref. |
Abstract |
The objective of this study was to investigate the risk of renal cell carcinoma (RCC) in Central and Eastern Europe in relation to exposure to known and suspected carcinogenic metals. During 1999-2003, a hospital-based study was conducted in the Czech Republic, Poland, Romania and Russia, including 1097 cases of RCC and 1476 controls. Occupational exposure to arsenic, cadmium, chromium, lead and nickel was assessed by teams of local industrial hygiene experts, based on detailed occupational questionnaires. The odds ratios (ORs) for RCC were 1.55 for exposure to lead and 1.40 for exposure to cadmium. No clear monotonic exposure-response relation was apparent for either duration of exposure or cumulative exposure to either metal, although the OR for the highest category of cumulative exposure to lead was 2.25. Exposure to other metals did not entail an increased risk of RCC.
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Descriptors (primary) |
chromium and compounds; nickel and compounds; arsenic and compounds; cadmium and compounds; lead and compounds; renal cancer; risk factors |
Descriptors (secondary) |
Czech Republic; Poland; Romania; Russian Federation; exposure evaluation; questionnaire survey; case-control study; statistical evaluation; job-exposure relation |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology Toxic and dangerous substances
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Broad subject area(s) |
Occupational medicine, epidemiology Chemical safety
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Browse category(ies) |
Cancer and carcinogens Cadmium and compounds Arsenic and compounds Lead and compounds Nickel and compounds
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