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CISDOC database

Document ID (ISN)111958
CIS number 11-0682
ISSN - Serial title 0019-8366 - Industrial Health
Year 2010
Convention or series no.
Author(s) Sellappa S., Sadhanandhan B., Francis A., Vasudevan S.G.
Title Evaluation of genotoxicity in petrol station workers in South India using micronucleus assay
Bibliographic information Nov. 2010, Vol.48, No.6, p.852-856. 32 ref.
Internet access Evaluation_of_genotoxicity.pdf [in English]
Abstract In this study, the micronucleus (MN) frequency was assessed as a measure of genotoxicity in exfoliated cells of buccal mucosa extracted from 110 service station attendants and 100 controls. For each individual, 3000 exfoliated buccal cells were analyzed. The individuals used in the study were grouped based on their smoking, drinking alcoholic beverages, and tobacco chewing habits. After controlling for smoking, alcohol consumption, age and length of occupation, there was a significantly higher frequency of micronucleated cells among the workers exposed to gasoline than in the unexposed control population. The significant increase in the induction of the MN in the exposed population suggests that the studied individuals may be at a higher risk of developing cancer and therefore should be monitored for possible long-term adverse effects of the exposure.
Descriptors (primary) India; motor fuel; service stations and repair shops; genetic abnormalities; inhalation toxicity; risk factors
Descriptors (secondary) determination in tissues; experimental pathology; case-control study; statistical evaluation
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Commerce, services, offices
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Risk evaluation
Petroleum and natural gas industry