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Document ID (ISN)111937
CIS number 11-0527
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Dolk H., Armstrong B., Lachowycz K., Vrijheid M., Rankin J., Abramsky L., Boyd P.A., Wellesley D.
Title Ambient air pollution and risk of congenital anomalies in England, 1991-1999
Bibliographic information Apr. 2010, Vol.67, No.4. p.223-227. 27 ref.
Internet access Ambient_air_pollution.pdf [in English]
Abstract The objective of this study was to investigate whether there is an association between risk of congenital anomaly and exposure to air pollution in England during the 1990s. A geographical study was conducted across four regions of England using population-based congenital anomaly registers, 1991-1999. Exposure was measured as 1996 annual mean background sulphur dioxide (SO2), nitrogen dioxide (NO2) and particulate matter (PM10) concentrations. Poisson regression, controlling for maternal age, area socioeconomic deprivation and hospital catchment area was used to estimate relative risk for an increase in pollution from the 10th to the 90th centile. For non-chromosomal anomalies combined, relative risks were 0.99 for SO2, 0.97 for NO2 and 0.89 for PM10. For chromosomal anomalies, relative risks were 1.06 for SO2, 1.11 for NO2 and 1.18 for PM10. Raised risks were found for tetralogy of Fallot and SO2 (RR 1.38), NO2 (RR 1.44) and PM10 (RR 1.48), which is of interest in light of previously reported associations between this cardiac anomaly and other air pollutants.
Descriptors (primary) England; atmospheric pollution; geographical variables; embryotoxic effects; risk factors
Descriptors (secondary) nitrogen dioxide; sulfur dioxide; soot; exposure evaluation; statistical evaluation
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Air pollution
Antifertility and prenatal effects