|Document ID (ISN)||111937|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Dolk H., Armstrong B., Lachowycz K., Vrijheid M., Rankin J., Abramsky L., Boyd P.A., Wellesley D.
||Ambient air pollution and risk of congenital anomalies in England, 1991-1999
||Apr. 2010, Vol.67, No.4. p.223-227. 27 ref.
||Ambient_air_pollution.pdf [in English]
||The objective of this study was to investigate whether there is an association between risk of congenital anomaly and exposure to air pollution in England during the 1990s. A geographical study was conducted across four regions of England using population-based congenital anomaly registers, 1991-1999. Exposure was measured as 1996 annual mean background sulphur dioxide (SO2), nitrogen dioxide (NO2) and particulate matter (PM10) concentrations. Poisson regression, controlling for maternal age, area socioeconomic deprivation and hospital catchment area was used to estimate relative risk for an increase in pollution from the 10th to the 90th centile. For non-chromosomal anomalies combined, relative risks were 0.99 for SO2, 0.97 for NO2 and 0.89 for PM10. For chromosomal anomalies, relative risks were 1.06 for SO2, 1.11 for NO2 and 1.18 for PM10. Raised risks were found for tetralogy of Fallot and SO2 (RR 1.38), NO2 (RR 1.44) and PM10 (RR 1.48), which is of interest in light of previously reported associations between this cardiac anomaly and other air pollutants.
||England; atmospheric pollution; geographical variables; embryotoxic effects; risk factors
||nitrogen dioxide; sulfur dioxide; soot; exposure evaluation; statistical evaluation
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
Antifertility and prenatal effects