|Document ID (ISN)||111919|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||van Rooy F.G.B.G.J., Houba R., Palmen N., Zengeni M.M., Sander I., Spithoven J., Rooyackers J.M., Heederik D.J.J.
||A cross-sectional study among detergent workers exposed to liquid detergent enzymes
||Nov. 2009, Vol.66, No.11, p.759-765. 30 ref.
||The objective of this cross-sectional study was to investigate sensitisation and respiratory health among workers who produce liquid detergent products and handle liquid detergent enzymes. It involved 109 workers of a detergent products plant, who were interviewed for respiratory and allergic symptoms and who provided blood samples to examine sensitisation to enzymes. Those sensitised to ≥1 enzymes were referred for clinical evaluation. Workers and representatives were interviewed to characterise exposure qualitatively and estimate exposure semi-quantitatively. Workers were classified into three exposure groups with varying exposure profiles to enzymes, based on frequency, duration and level of exposure. Workers were exposed to proteases, alpha-amylases, lipase and cellulases. The highest exposures occurred in the mixing area. Liquid spills with concentrated enzyme preparations and leakage of enzymes during weighing, transportation and filling were causing workplace contaminations and subsequently leading to both dermal and inhalation exposure for workers. Workers with the highest exposures reported significantly more work-related symptoms of itching nose (prevalence ratio PR 4.2) and sneezing (PR 4.0) and marginally significant more symptoms of wheezing (PR 2.9) compared with the least exposed group. Fifteen workers (14.2%) were sensitised to ≥1 enzymes. A marginally-statistically significant gradient in sensitisation across the exposure categories was found. There was a clinical case of occupational asthma and two others with probable occupational rhinitis. Implications of these findings are discussed.
||enzyme detergents; sensitization; respiratory diseases; detergent industry; risk factors
||Netherlands; amylase; lipase; proteases; exposure evaluation; statistical evaluation; dose-response relationship
||D - Periodical articles
||Chemicals, plastics and rubber
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
Diseases of the respiratory system (except for pneumoconiosis & similar)