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Document ID (ISN)111918
CIS number 11-0518
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2009
Convention or series no.
Author(s) Panasevich S., Leander K., Rosenlund M., Ljungman P., Bellander T., de Faire U., Pershagen G., Nyberg F.
Title Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample
Bibliographic information Nov. 2009, Vol.66, No.11, p.747-753. Illus. 38 ref.
Abstract Exposure to elevated levels of ambient air pollutants can lead to adverse cardiovascular effects. Potential mechanisms include systemic inflammation and perturbation of the coagulation balance. The objective of this study was to investigate the long- and short-term effects of air pollution exposure on serum levels of inflammatory and coagulation markers relevant for cardiovascular pathology. The study group consisted of a population sample of 1028 men and 508 women aged 45-70 years from Stockholm. Long-term air pollution exposure was assessed using spatial modelling of traffic-related NO2 and heating-related SO2 emissions at each subject's residential addresses over retrospective periods of 1,5 and 30 years. Short-term exposure was assessed as averages of rooftop measurements over 12-120 h before blood sampling. Long-term exposures to both traffic-NO2 and heating-SO2 emissions showed consistent associations with IL-6 levels. 30-year average traffic-NO2 exposure was associated with a 64.5% increase in serum IL-6 per 28.8 μg/m3 and 30-year exposure to heating- SO2 with a 67.6% increase per 39.4 μg/m3. The association appeared stronger in non-smokers, physically active people and hypertensive subjects. Short-term exposure to O3 was associated with increased, and SO2 with decreased, fibrinogen levels. These results suggest that exposure to moderate levels of air pollution may influence serum levels of inflammatory markers.
Descriptors (primary) atmospheric pollution; cardiovascular diseases; exposure evaluation; risk factors
Descriptors (secondary) Sweden; nitrogen dioxide; ozone; sulfur dioxide; interleukins; blood coagulation; determination in blood
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Environmental pollution
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Air pollution
Cardiovascular diseases
Exposure evaluation
Risk evaluation