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Document ID (ISN)111912
CIS number 11-0513
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2009
Convention or series no.
Author(s) MacCarthy A., Bunch K.J., Fear N.T, King J.C., Vincent T.J., Murphy M.F.
Title Paternal occupation and retinoblastoma: A case-control study based on data for Great Britain 1962-1999
Bibliographic information Oct. 2009, Vol.66, No.10, p.644-649. 22 ref.
Abstract The objective of this study was to examine the association between paternal occupational exposures and retinoblastoma using birth registration data for cases from the National Registry of Childhood Tumours (NRCT) and controls from the general population of Great Britain. It was conducted in the form of a case-control study of paternal occupational data for 1318 cases of retinoblastoma, born and diagnosed between 1962 and 1999, and 1318 controls matched on sex, date of birth and birth registration sub-district. Paternal occupations at birth were grouped according to inferred exposure using an occupational exposure classification scheme. A conditional (matched) case-control analysis was used to estimate odds ratios (ORs) for each paternal occupational exposure group. For non-heritable retinoblastoma, a statistically significant increased risk was found with father's definite occupational exposure to oil mists in metal working (OR 1.85). No statistically significant associations were observed for other exposure groups.
Descriptors (primary) cancer; retinal damage; children; parental exposure; risk factors
Descriptors (secondary) oil mist; cutting fluids; case-control study; metalworking industry
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens
Risk evaluation
Metalworking industry