|Document ID (ISN)||111912|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||MacCarthy A., Bunch K.J., Fear N.T, King J.C., Vincent T.J., Murphy M.F.
||Paternal occupation and retinoblastoma: A case-control study based on data for Great Britain 1962-1999
||Oct. 2009, Vol.66, No.10, p.644-649. 22 ref.
||The objective of this study was to examine the association between paternal occupational exposures and retinoblastoma using birth registration data for cases from the National Registry of Childhood Tumours (NRCT) and controls from the general population of Great Britain. It was conducted in the form of a case-control study of paternal occupational data for 1318 cases of retinoblastoma, born and diagnosed between 1962 and 1999, and 1318 controls matched on sex, date of birth and birth registration sub-district. Paternal occupations at birth were grouped according to inferred exposure using an occupational exposure classification scheme. A conditional (matched) case-control analysis was used to estimate odds ratios (ORs) for each paternal occupational exposure group. For non-heritable retinoblastoma, a statistically significant increased risk was found with father's definite occupational exposure to oil mists in metal working (OR 1.85). No statistically significant associations were observed for other exposure groups.
||cancer; retinal damage; children; parental exposure; risk factors
||oil mist; cutting fluids; case-control study; metalworking industry
||D - Periodical articles
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
||Cancer and carcinogens