|Document ID (ISN)||111792|
|Convention or series no.
||McKinney P.A., Raji O.Y., Feltbower R.G., Van Tongeren M.
Health and Safety Executive
||Parental occupational chemical exposures and childhood cancer
||HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2008. xii, 130p. Illus. Approx. 220 ref.
||RR_661.pdf [in English]
||Interview data from the United Kingdom Childhood Cancer Study, an epidemiological case control study, was used to extend and refine previous analyses of parental occupations. Specific work-related exposures were examined as possible risk factors for childhood leukaemia and lymphoma for three exposure time windows (preconception, pregnancy, postnatal). Mothers had a lower prevalence of exposure to chemical agents at work (18%) compared to fathers (44%). In order to refine exposure assessment all available data was examined. Parents self-reported being exposed in over 24,000 jobs; the reviewed exposure assessment reduced the numbers of reported exposures, reclassifying 33% of mothers and 50% of fathers as exposed. Many statistically significant risks for self-reported exposure disappeared when applying the reclassified exposure. For the refined exposure assessment, maternal exposure to solvents during pregnancy remained a statistically significant risk for acute lymphoblastic leukaemia with a dose-response relationship. Paternal exposure to fertilizers during pregnancy and post-natally were associated with acute lymphoblastic leukaemia and Hodgkin lymphoma but without dose-response relationships.
||United Kingdom; chemical products; cancer; children; parental exposure
||fertilizers; solvents; lymphoma; leukaemia; case-control study; statistical evaluation; public OSH institutions; research; dose-response relationship; report
||E - Books, reports, proceedings
|Country / State or Province||United Kingdom|
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
||Cancer and carcinogens