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Document ID (ISN)111792
CIS number 11-0470
Year 2008
Convention or series no. RR 661
Author(s) McKinney P.A., Raji O.Y., Feltbower R.G., Van Tongeren M.
Health and Safety Executive
Title Parental occupational chemical exposures and childhood cancer
Bibliographic information HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2008. xii, 130p. Illus. Approx. 220 ref.
Internet access RR_661.pdf [in English]
Abstract Interview data from the United Kingdom Childhood Cancer Study, an epidemiological case control study, was used to extend and refine previous analyses of parental occupations. Specific work-related exposures were examined as possible risk factors for childhood leukaemia and lymphoma for three exposure time windows (preconception, pregnancy, postnatal). Mothers had a lower prevalence of exposure to chemical agents at work (18%) compared to fathers (44%). In order to refine exposure assessment all available data was examined. Parents self-reported being exposed in over 24,000 jobs; the reviewed exposure assessment reduced the numbers of reported exposures, reclassifying 33% of mothers and 50% of fathers as exposed. Many statistically significant risks for self-reported exposure disappeared when applying the reclassified exposure. For the refined exposure assessment, maternal exposure to solvents during pregnancy remained a statistically significant risk for acute lymphoblastic leukaemia with a dose-response relationship. Paternal exposure to fertilizers during pregnancy and post-natally were associated with acute lymphoblastic leukaemia and Hodgkin lymphoma but without dose-response relationships.
Descriptors (primary) United Kingdom; chemical products; cancer; children; parental exposure
Descriptors (secondary) fertilizers; solvents; lymphoma; leukaemia; case-control study; statistical evaluation; public OSH institutions; research; dose-response relationship; report
Document type E - Books, reports, proceedings
Country / State or ProvinceUnited Kingdom
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens
Agricultural chemicals