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CISDOC database

Document ID (ISN)111687
CIS number 11-0415
ISSN - Serial title 1745-6673 - Journal of Occupational Medicine and Toxicology
Year 2011
Convention or series no.
Author(s) Adelman C., Weinberger J.M., Kriksunov L., Sohmer H.
Title Effects of furosemide on the hearing loss induced by impulse noise
Bibliographic information 2011, No.6:14. 19p. 24 ref.
Internet access Effects_of_furosemide.pdf [in English]
Abstract The permanent hearing loss following exposure to intense noise can be due either to mechanical structural damage (tearing) caused directly by the noise or to metabolic (biochemical) damage resulting from the elevated levels of free radicals released during transduction of the sound overstimulation. Drugs which depress active cochlear mechanics (for example furosemide and salicylic acid) or anti-oxidants (which counteract the free radicals) are effective in reducing the threshold shift (TS) following broadband continuous noise. This study was designed to determine whether furosemide can reduce the TS following exposure to impulse noise, similar to its action with continuous broadband noise. Shortly after furosemide injection, mice were exposed to simulated M16 rifle impulse noise produced by loudspeakers and amplifiers in different exposure settings and, in other experiments, also to actual M16 rifle shots. The drug was partially effective in reducing the TS to simulated noise, but not to actual impulse noise. Implications of these findings are discussed.
Descriptors (primary) impulse noise; furosemide; hearing loss; medical treatment
Descriptors (secondary) protective pharmacological agents; hearing threshold; animal experiments
Document type D - Periodical articles
Subject(s) Noise, hearing and vibration
Broad subject area(s) Physical hazards
Browse category(ies) Noise
Diseases of the ear and hearing damage