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Document ID (ISN)111675
CIS number 11-0342
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2011
Convention or series no.
Author(s) Makol A., Reilly M.J., Rosenman K.D.
Title Prevalence of connective tissue disease in silicosis (1985-2006) - A report from the State of Michigan surveillance system for silicosis
Bibliographic information 2011, Vol.54, p.255-262. 40 ref.
Abstract The risk of developing clinical connective tissue disease (CTD) has been reported to be increased among individuals with silica exposure. This study consisted of reviewing the medical records of individuals reported to the Michigan Silicosis Surveillance system from 1985 to 2006 to confirm the diagnosis of silicosis and determine the presence of CTDs. From 1985 to 2006, 1,022 cases were confirmed to have silicosis. Medical records of 790 cases were available. Thirty-three individuals had rheumatoid arthritis (prevalence 4.2%, prevalence ratio (RR) ranging from 2.26 to 6.96 depending on the reference rate used), two had scleroderma (prevalence 0.3%, RR 28.3), one had systemic lupus erythematosus (prevalence 0.1%, RR 2.53), two had Sjogrens syndrome (prevalence 0.3%, RR 0.42) and six had anti-neutrophil cytoplasm antibody (ANCA) vasculitis (prevalence 0.8%, RR 25.3). There was no difference between those with and without CTD with respect to age, race, industry type, history of tuberculosis, application for workers' compensation, or severity of fibrotic changes on chest X-ray. Implications of these findings are discussed.
Descriptors (primary) Michigan; connective tissue disorders; silicosis; risk factors
Descriptors (secondary) USA; statistical evaluation; health service records; frequency rates
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Pneumoconioses
Risk evaluation