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CISDOC database

Document ID (ISN)111648
CIS number 11-0387
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2010
Convention or series no.
Author(s) Mehta A.J., Malloy E.J., Applebaum K.M., Schwartz J., Christiani D.C., Eisen E.A.
Title Reduced lung cancer mortality and exposure to synthetic fluids and biocide in the auto manufacturing industry
Bibliographic information Nov. 2010, Vol.36, No.6, p.499-508. Illus. 38 ref.
Abstract Water-based soluble and synthetic metalworking fluids (MWFs) used in automotive industry may be contaminated by endotoxin from Gram-negative bacteria, a possible anti-carcinogen. This study investigated whether an inverse relationship between lung cancer and synthetic MWF and biocide persisted in an extended follow-up of autoworkers. A nested case-control analysis was performed within a retrospective cohort study of 46,399 automotive industry workers. Follow-up began in 1941 and was extended from 1985-1995. Mortality rate ratios for lung cancer were estimated in Cox regression models. Results suggest a non-linear inverse exposure-response for lung cancer mortality with increasing endotoxin exposure. Overall, the greatest reduction in mortality was observed among those with the highest exposure. Effect modification by biocides was marginally significant. The protective effect of synthetic MWFs against lung cancer mortality persisted through the extended period of follow-up, although attenuated, and was observed only among workers with co-exposure to biocide and synthetic MWFs.
Descriptors (primary) USA; biocides; cutting fluids; mortality; lung cancer; motor vehicle industry; risk factors
Descriptors (secondary) bacterial toxins; long-term study; cohort study; statistical evaluation; long-term exposure
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Occupational pathology
Broad subject area(s) Chemical safety
Biological hazards
Browse category(ies) Cancer and carcinogens
Diseases of the respiratory system (except for pneumoconiosis & similar)
Motor vehicle manufacturing industry