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Document ID (ISN)111367
CIS number 11-0084
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2011
Convention or series no.
Author(s) Lin M.H., Liou S.H., Chang C.W., Huang I.H., Strickland P.T., Lai C.H.
Title An engineering intervention resulting in improvement in lung function and change in urinary 8-hydroxydeoxyguanosine among foundry workers in Taiwan
Bibliographic information 2011, Vol. 84, p.175-183. Illus. 27 ref.
Abstract The objective of this study was to assess changes in oxidative DNA damage and lung function in a group of foundry workers following an engineering intervention to reduce respirable dust in their working environment. All 22 workers from a typical small Taiwanese iron foundry plant were studied before and three months after improvements to air exhaust control. The effectiveness of the air exhaust intervention in reducing respirable dust and SiO2 was determined by personal breathing-zone air sampling. Initial baseline biomarker measurements were taken of lung function and urinary 8-hydroxy-deoxyguanosine (8-OHdG) in all of the workers, with follow-up measurements taken three months after the engineering control was put in place. Generalized estimating equations were used to assess the effect of the intervention on lung function and oxidative DNA damage. Findings indicate that reductions in workplace respirable dust and SiO2 concentration can result in improved lung function amongst foundry workers.
Descriptors (primary) Taiwan (China); silica; respirable dust; pulmonary function; exposure tests; limitation of exposure; foundries
Descriptors (secondary) oxidation; small enterprises; determination in urine; respiratory function tests; exhaust ventilation
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Foundries, metalcasting and forging operations
Silicon compounds