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Document ID (ISN)111344
CIS number 11-0073
ISSN - Serial title 1745-6673 - Journal of Occupational Medicine and Toxicology
Year 2010
Convention or series no.
Author(s) Viegas S., Ladeira C., Nunes C., Malta-Vacas J., Gomes M., Brito M., Mendonša P., Prista J.
Title Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production
Bibliographic information 2010, 5:25, 8p. 49 ref.
Internet access Genotoxic_effects.pdf [in English]
Abstract Presently, the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to humans (Group 1), based on sufficient evidence in humans and in experimental animals. Numerous in vitro studies clearly indicated that formaldehyde can induce genotoxic effects in proliferating cultured mammalian cells. Furthermore, some in vivo studies have found changes in epithelial cells and in peripheral blood lymphocytes related to formaldehyde exposure. This study was carried out in Portugal, using 80 workers occupationally exposed to formaldehyde vapours: 30 workers from formaldehyde and formaldehyde-based resins production factory and 50 from 10 pathology and anatomy laboratories. A group of 85 non-exposed subjects was used as control. Exposure was measured by NIOSH Method 2541, photo ionization detection and video recordings. Genotoxic effects were evaluated by the micronucleus test in exfoliated epithelial cells from buccal mucosa and peripheral blood lymphocytes. Time-weighted average concentrations did not exceed the reference value (0.75 ppm) in the two occupational settings studied. However peak concentrations were higher than reference value (0.3 ppm) in both. The frequency of micronucleus in peripheral blood lymphocytes and in epithelial cells was significantly higher in both exposed groups than in the control group. Moreover, the frequency of micronucleus in peripheral blood lymphocytes was significantly higher in the laboratories group than among the factory workers. A moderate positive correlation was found between duration of occupational exposure to formaldehyde (years of exposure) and micronucleus frequency in peripheral blood lymphocytes and in epithelial cells.
Descriptors (primary) formaldehyde; DNA; blood-cell anomalies; genetic effects; risk factors
Descriptors (secondary) Portugal; toxic substances; anatomy; cell culture; histopathology; case-control study; plastics converting industry
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aldehydes