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Document ID (ISN)111343
CIS number 11-0040
ISSN - Serial title 1745-6673 - Journal of Occupational Medicine and Toxicology
Year 2010
Convention or series no.
Author(s) Tamir S., Adelman C., Weinberger J.M., Sohmer H.
Title Uniform comparison of several drugs which provide protection from noise induced hearing loss
Bibliographic information 2010, 5:26, 7p. Illus. 20 ref.
Internet access Uniform_comparison_of_several_drugs.pdf [in English]
Abstract The ability of drugs to reduce noise induced hearing loss (NIHL) has been evaluated in diverse experimental conditions (animal species, noise intensities, durations, assessment techniques, etc.), making it difficult to assess their relative efficacy. The present study was designed to provide more uniform comparisons and to allow a better understanding of the mechanism of the NIHL. The drugs studied included furosemide and the antioxidants N-acetyl-L-cysteine, vitamins A, C, E with the vasodilator magnesium. Mice were exposed to a continuous broadband noise (113 dB SPL for 3.5 hours) and the NIHL was assessed in all animals before noise exposure and 1 week after with auditory nerve brainstem evoked responses (ABR) to broadband clicks and to 8 kHz tone bursts. Each of the drugs alone and in combination led to similar reductions in NIHL.
Descriptors (primary) noise; hearing loss; pharmacological prevention
Descriptors (secondary) magnesium; mercapturic acid; furosemide; vitamin C; vitamin A; vitamin E; animal experiments; comparative study; reliability; description of technique
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Physical hazards
Browse category(ies) Diseases of the ear and hearing damage
Workplace health promotion
Noise