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Document ID (ISN)111278
CIS number 10-0840
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2010
Convention or series no.
Author(s) Uzma N., Kumar B.S., Hazari M.A.H.
Title Exposure to benzene induces oxidative stress, alters the immune response and expression of p53 in gasoline filling workers
Bibliographic information 2010, Vol.53, p.1264-1270. Illus. 34 ref.
Abstract This study investigated the adverse effects of benzene among workers occupationally exposed to benzene in India. It involved 428 gasoline filling workers occupationally exposed to benzene and 78 unexposed individuals. A significant increase in the concentration of benzene and its byproducts in both blood and urine were found in the workers compared with the controls. Occupational exposure to benzene causes oxidative stress, immune suppression and increases the expression of tumor-suppressing gene p53 in gasoline filling workers. These bio-functional markers might be useful in screening and surveillance for occupational hazard.
Descriptors (primary) India; benzene; service stations and repair shops; exposure tests
Descriptors (secondary) oxidation; immunobiological changes; determination in blood; determination in urine; case-control study
Document type D - Periodical articles
Subject(s) Commerce, services, offices
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Petroleum and natural gas industry
Aromatic hydrocarbons
Biological monitoring