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Document ID (ISN)111268
CIS number 10-0836
ISBN(s) 978-2-89631-423-2
Year 2010
Convention or series no. Etudes et recherches - Rapport R-637
Author(s) Muller C., Mazer B., Salehi F., Audusseau S., Truchon G., Lambert J., L Espérance G., Chevalier G., Philippe S., Cloutier Y., Larivière P., Zayed J.
Title Evaluation of beryllium toxicity based on the chemical form and particle size
Original title Evaluation de la toxicité du béryllium en fonction de la forme chimique et de la taille des particules [in French]
Bibliographic information Institut de recherche Robert-Sauvé en santé et en sécurité du travail du Québec (IRSST), 505 boul. de Maisonneuve Ouest, Montreal (Quebec) H3A 3C2, Canada, 2010. viii, 45p. Illus. 51 ref. Price: CAD 8.40. Downloadable version (PDF format) free of charge.
Internet access Rapport_R-637.pdf [in French]
Abstract In recent years, various studies have been questioning the level of protection offered to workers by the threshold value for beryllium (Be) and its salts. The objective of this study was to verify, using an animal model, to what extent pulmonary effects are related to the chemical form of Be and the particle size. The results obtained confirm numerous correlations between tissue concentrations of Be and pulmonary effects similar to those observed in a worker following exposure. The results also reveal an association between particle size, lung concentrations, pulmonary inflammation, the production of certain cytokines, and the expression of certain lymphocytes. The effects also depend on the chemical form of Be. Clearly, the aerodynamic diameter and solubility played a significant role in pulmonary deposition and retention.
Descriptors (primary) Quebec; beryllium and compounds; airborne dust; particle size; toxicology; animal experiments; inhalation toxicity; risk factors
Descriptors (secondary) Canada; beryllium; beryllium oxide; aerodynamic size; particle surface area; beryllium-aluminium alloy; lung deposition; public OSH institutions; report
Document type E - Books, reports, proceedings
Country / State or ProvinceQuebec
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Toxicology
Diseases of the respiratory system (except for pneumoconiosis & similar)