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Document ID (ISN)111085
CIS number 10-0683
ISBN(s) 978-2-89631-355-6
Year 2009
Convention or series no. Etudes et Recherches Rapport R-604
Author(s) Vyskocil A., Leroux T., Truchon G., Lemay F., Gendron M., Lim S., El Majidi N., Botez S., Emond C., Viau C.
Title Chemical substances and effect on hearing - Literature review
Original title Substances chimiques et effet sur l'audition - Revue de la littérature [in French]
Bibliographic information Institut de recherche Robert-Sauvé en santé et en sécurité du travail du Québec (IRSST), 505 boul. de Maisonneuve Ouest, Montreal (Quebec) H3A 3C2, Canada, 2009. v, 31p. 162 ref. Price: CAD 9.45. Downloadable version (PDF format) free of charge.
Internet access Rapport_R-604.pdf [in French]
Abstract In the context of a systematic literature analysis on chemical substances and their effects on hearing, this study evaluated the robustness of the methodologies used for measuring these effects and examined the consistency and differences that existed between studies on a given substance. It then developed a "decision grid" for evaluating the strength of proof of a causal relationship between exposure to the substances studied and the impact on hearing. The studied substances were classified according to four types of conclusions: the substance is ototoxic; it is possibly ototoxic; its ototoxicity has not been conclusively proven; there is no proof of ototoxicity. According to this method, ototoxic substances are: lead, styrene, toluene and trichloroethylene. Substances that are possibly ototoxic are: ethylbenzene, n-hexane and xylene.
Descriptors (primary) Quebec; harmful substances; chemical products; toxicity evaluation; ototoxic effects
Descriptors (secondary) Canada; lead and compounds; hexane; toluene; xylene; ethylbenzene; styrene; trichloroethylene; literature survey; report; classification
Document type E - Books, reports, proceedings
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the ear and hearing damage