| Document ID (ISN) | 111016 |
| CIS number |
10-0554 |
| ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Year |
2010 |
| Convention or series no. |
|
| Author(s) |
Larson T.C., Antao V.C., Bove F.J. |
| Title |
Vermiculite worker mortality: Estimated effects of occupational exposure to Libby amphibole |
| Bibliographic information |
May 2010, Vol.52, No.5, p.555-560. 34 ref. |
| Abstract |
The objective of this study was to examine the relationship between cumulative fibre exposure (CFE) and mortality in a cohort of 1862 vermiculite workers exposed to Libby amphibole. Extended Cox regression was used to estimate the hazards associated with CFE as a time-dependent covariate of multiple-cause mortality. The Cox models for mesothelioma, asbestosis, lung cancer, and non-malignant respiratory disease were significant with rate ratios that increased monotonically with CFE. The model for deaths due to cardiovascular disease was also significant. By using a within-cohort comparison, the results demonstrate a clear exposure-response relationship between CFE and mortality from asbestos-related causes. The finding of an association between CFE and cardiovascular mortality suggests persons exposed to Libby amphibole should be monitored for this outcome. |
| Descriptors (primary) |
USA; amphibole; vermiculite; mortality; mining industry |
| Descriptors (secondary) |
mesothelioma; cardiovascular diseases; respiratory diseases; lung cancer; asbestosis; cohort study; statistical evaluation |
| Document type |
D - Periodical articles |
| Subject(s) |
Mines and quarries
Occupational pathology
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
Occupational medicine, epidemiology
|
| Browse category(ies) |
Mining and quarrying
|
