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Document ID (ISN)110982
CIS number 10-0548
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2010
Convention or series no.
Author(s) He J., Wang P., Zhu J.Q., Wu G., Ji J.M., Xue Y.
Title Role of urinary biomarkers of N,N-dimethylformamide in the early detection of hepatic injury among occupational exposed workers
Bibliographic information Apr. 2010, Vol.83, No.4, p.399-406. 26 ref.
Abstract The objective of this study was to identify sensitive and convenient biomarkers for the early detection of hepatic injury in N,N-dimethylformamide (DMF) exposed workers. Seventy-nine workers at a synthetic leather factory were investigated by means of a questionnaire survey. Air, urine and blood samples were collected at the specific time point. Airborne DMF and the urine metabolites of DMF were measured by gas chromatography (GC), high-performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS). Traditional liver function tests and hepatic fibrosis parameters were performed by auto-chemistry analyzer and ELISA methods. It was found that workers exposed to DMF with higher N-acetyl-S-(N-methylcarbamoyl)-cysteine levels were more likely to develop liver diseases. In addition, serum bile acid and hyaluronidase have the potential to act as early indicators of toxic hepatic fibrosis activities for occupational health surveillance.
Descriptors (primary) dimethylformamide; diagnosis; hepatic damage; exposure tests
Descriptors (secondary) China; metabolic process; liver fibrosis; sampling and analysis; determination in air; determination in blood; determination in urine; mass spectrometry; gas chromatography; high performance chromatography; liver function tests; exposure evaluation; reliability
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Amides
Biological monitoring
Liver diseases