|Document ID (ISN)||110982|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||He J., Wang P., Zhu J.Q., Wu G., Ji J.M., Xue Y.
||Role of urinary biomarkers of N,N-dimethylformamide in the early detection of hepatic injury among occupational exposed workers
||Apr. 2010, Vol.83, No.4, p.399-406. 26 ref.
||The objective of this study was to identify sensitive and convenient biomarkers for the early detection of hepatic injury in N,N-dimethylformamide (DMF) exposed workers. Seventy-nine workers at a synthetic leather factory were investigated by means of a questionnaire survey. Air, urine and blood samples were collected at the specific time point. Airborne DMF and the urine metabolites of DMF were measured by gas chromatography (GC), high-performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS). Traditional liver function tests and hepatic fibrosis parameters were performed by auto-chemistry analyzer and ELISA methods. It was found that workers exposed to DMF with higher N-acetyl-S-(N-methylcarbamoyl)-cysteine levels were more likely to develop liver diseases. In addition, serum bile acid and hyaluronidase have the potential to act as early indicators of toxic hepatic fibrosis activities for occupational health surveillance.
||dimethylformamide; diagnosis; hepatic damage; exposure tests
||China; metabolic process; liver fibrosis; sampling and analysis; determination in air; determination in blood; determination in urine; mass spectrometry; gas chromatography; high performance chromatography; liver function tests; exposure evaluation; reliability
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology