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CISDOC database

Document ID (ISN)110957
CIS number 10-0562
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Krajnak K., Miller G.R., Waugh S., Johnson C., Li S., Kashon M.L.
Title Characterization of frequency-dependent responses of the vascular system to repetitive vibration
Bibliographic information June 2010, Vol.52, No.6, p.584-594. Illus. 52 ref.
Abstract The current frequency weighting proposed in the ISO 5349 standard may underestimate the risk of injury associated with exposure to vibrations of frequencies above 100 Hz. The goal of this study was to assess the frequency-dependent responses of the peripheral vascular system to repeated bouts of vibration. The effects of exposure to vibration at 62.5, 125 and 250 Hz (constant acceleration of 49 m/s2) on vascular morphology, oxidative stress, inflammation, and gene expression were examined in the ventral tail artery of rats. Vascular responses indicative of dysfunction (such as remodelling and oxidative activity) became more pronounced as the frequency of the exposure increased.
Descriptors (primary) vibration frequency; peripheral circulation; dose-response relationship
Descriptors (secondary) vibration acceleration; oxidation; inflammations; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Physical hazards
Browse category(ies) Vibration