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Document ID (ISN)110955
CIS number 10-0543
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Schwartz B.S., Caffo B., Stewart W.F., Hedlin H., James B.D., Yousem D., Davatzikos C.
Title Evaluation of cumulative lead dose and longitudinal changes in structural magnetic resonance imaging in former organolead workers
Bibliographic information Apr. 2010, Vol.52, No.4, p.407-414. Illus. 38 ref.
Abstract This study evaluated whether tibia lead was associated with longitudinal change in brain volumes and white matter lesions among male former lead workers and population-based controls in whom cognitive and structural consequences of cumulative lead dose had been previously reported. Linear regression was used to identify predictors of change in brain volumes and white matter lesion grade scores, using two magnetic resonance imaging scans an average of five years apart. On average, total brain volume declined almost 30cm3, predominantly in gray matter. Increasing age at the first magnetic resonance imaging was strongly associated with larger declines in volumes and greater increases in white matter lesion scores. Tibia lead was not associated with change in brain volumes or white matter lesion scores. Results showed that in former lead workers in whom cumulative lead dose was associated with progressive declines in cognitive function decades after occupational exposure had ended, cumulative lead dose was associated with earlier persistent effects on brain structure but not with additional worsening during five years.
Descriptors (primary) lead; brain; magnetic resonance imaging; cumulative properties
Descriptors (secondary) brain tissue damage; tibia; case-control study
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Lead and compounds