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CISDOC database
Document ID (ISN) | 110855 |
CIS number |
10-0435 |
ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
Year |
2010 |
Convention or series no. |
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Author(s) |
Suwazono Y., Uetani M., Oishi M., Tanaka K., Morimoto H., Nakada S., Sakata K. |
Title |
Estimation of the benchmark duration of alternating shift work associated with increased total cholesterol levels among male Japanese workers |
Bibliographic information |
Mar. 2010, Vol.36, No.2, p.142-149. 28 ref. |
Abstract |
The aim of this study was to estimate the benchmark doses and their 95% lower confidence limits for the threshold number of years of alternating shift work associated with a relative increase in serum total cholesterol level (T-Cho), as an index of lipid metabolism. A 14-year prospective cohort study was conducted among 6886 male workers at a Japanese steel company who had received annual health check-ups between 1991 and 2005. The endpoints were either a 20, 25, 30, 35, 40 or 45% increase in T-Cho levels during the observation period, compared to T-Cho at baseline. The associations between the years of alternating shift work and the relative increases in T-Cho were investigated using pooled logistic regression, adjusted for other potential covariates. The threshold number of years of alternating shift work that caused a 5% increase in T-Cho among middle-aged workers was shown to be 21 years or more. Implications of these findings are discussed. |
Descriptors (primary) |
cholesterol; shift work; lipid metabolism; length of exposure; risk factors |
Descriptors (secondary) |
Japan; determination in blood; cohort study; statistical evaluation; male workers; iron and steel industry |
Document type |
D - Periodical articles |
Subject(s) |
Occupational physiology
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Broad subject area(s) |
Physiology, ergonomics
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Browse category(ies) |
Iron and steel industry Metabolic diseases
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