|Document ID (ISN)||110798|
|ISSN - Serial title
||0019-8366 - Industrial Health
|Convention or series no.
||Bhargava A.;, Punde R.P, Pathak N.;, Dabadghao S, Desikan P.;, Jain A.;, Maudar K.K.;, Mishra P.K.
||Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: A study after two decades
||Mar. 2010, Vol.48, No.2, p.204-208. Illus. 32 ref.
||Status_of_inflammatory_biomarkers.pdf [in English]
||Bhopal gas tragedy is considered as one of the world's worst industrial disaster. Approximately, 3,000-6,000 people died and 200,000 were injured due to the leak of 40 tons of methyl isocyanate (MIC) gas from a pesticide plant. This study aimed to decipher any persistent and subtle immunotoxic effects of MIC in the survivors of the tragedy. Participants were divided into three groups: age and gender matched non-exposed healthy controls recruited from places within the geographical region of Bhopal but from unaffected zones; age and gender matched non-exposed healthy controls recruited from places well outside geographical region of Bhopal; age and gender matched MIC exposed subjects from affected zones inside geographical region of Bhopal. The status of inflammatory biomarkers (IL-8, IL-1β, IL-6, TNF, IL-10, IL-12p70 cytokines and C-reactive protein) in these three groups was analysed. The results displayed a significant increase in the levels of all circulating inflammatory biomarkers in the MIC exposed group in comparison to non-exposed cohorts. A toxin-induced genetic and/or epigenetic alteration seems to be the likely underlying cause. However, further studies are essential for both mechanistic understanding and clinical implications of these patterns.
||India; methyl isocyanate; pesticides; gas explosions; major hazards; immunotoxic effects; survival
||biochemical substances; interleukins; long-term study; case-control study; genetic effects; disasters
||D - Periodical articles
||Chemicals, plastics and rubber
|Broad subject area(s)
||Occupational medicine, epidemiology
Fires, explosions and major hazards
Genetic factors in reaction to exposures