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Document ID (ISN)110798
CIS number 10-0345
ISSN - Serial title 0019-8366 - Industrial Health
Year 2010
Convention or series no.
Author(s) Bhargava A.;, Punde R.P, Pathak N.;, Dabadghao S, Desikan P.;, Jain A.;, Maudar K.K.;, Mishra P.K.
Title Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: A study after two decades
Bibliographic information Mar. 2010, Vol.48, No.2, p.204-208. Illus. 32 ref.
Internet access Status_of_inflammatory_biomarkers.pdf [in English]
Abstract Bhopal gas tragedy is considered as one of the world's worst industrial disaster. Approximately, 3,000-6,000 people died and 200,000 were injured due to the leak of 40 tons of methyl isocyanate (MIC) gas from a pesticide plant. This study aimed to decipher any persistent and subtle immunotoxic effects of MIC in the survivors of the tragedy. Participants were divided into three groups: age and gender matched non-exposed healthy controls recruited from places within the geographical region of Bhopal but from unaffected zones; age and gender matched non-exposed healthy controls recruited from places well outside geographical region of Bhopal; age and gender matched MIC exposed subjects from affected zones inside geographical region of Bhopal. The status of inflammatory biomarkers (IL-8, IL-1β, IL-6, TNF, IL-10, IL-12p70 cytokines and C-reactive protein) in these three groups was analysed. The results displayed a significant increase in the levels of all circulating inflammatory biomarkers in the MIC exposed group in comparison to non-exposed cohorts. A toxin-induced genetic and/or epigenetic alteration seems to be the likely underlying cause. However, further studies are essential for both mechanistic understanding and clinical implications of these patterns.
Descriptors (primary) India; methyl isocyanate; pesticides; gas explosions; major hazards; immunotoxic effects; survival
Descriptors (secondary) biochemical substances; interleukins; long-term study; case-control study; genetic effects; disasters
Document type D - Periodical articles
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Fires, explosions and major hazards
Browse category(ies) Agricultural chemicals
Isocyanates
Major hazards
Explosions
Genetic factors in reaction to exposures
Toxicology