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CISDOC database

Document ID (ISN)110403
CIS number 09-1228
ISSN - Serial title 0019-8366 - Industrial Health
Year 2009
Convention or series no.
Author(s) Dai Y., Leng S., Li L., Niu Y., Huang H., Liu Q., Duan H., Cheng J., Zheng Y.
Title Effects of genetic polymorphisms of N-acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers
Bibliographic information Sep. 2009, Vol.47, No.5, p.479-486. 41 ref.
Internet access http://www.jniosh.go.jp/en/indu_hel/pdf/IH_47_5_479.pdf [in English]
Abstract This case-control study was conducted to investigate effects of various genotypes and phenotypes of N-acetyltransferases (NATs) on individual susceptibility to trichloroethylene (TCE)-induced hypersensitivity dermatitis. The study involved 111 patients with hypersensitivity dermatitis and 154 healthy TCE-exposed workers. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the polymorphic sites of NATs. Data were subjected to logistic regression analyses. Findings are discussed.
Descriptors (primary) sensitization dermatitis; individual susceptibility; trichloroethylene
Descriptors (secondary) DNA; transferases; statistical evaluation; genetic effects; case-control study
Document type D - Periodical articles
Country / State or ProvinceChina
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Skin diseases
Halogenated hydrocarbons
Genetic factors in reaction to exposures