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Document ID (ISN)110292
CIS number 09-1335
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2009
Convention or series no.
Author(s) González-Yebra A.L., Kornhauser C., Barbosa-Sabanero G., Pérez-Luque E.L., Wrobel K.
Title Exposure to organic solvents and cytogenetic damage in exfoliated cells of the buccal mucosa from shoe workers
Bibliographic information Feb. 2009, Vol.82, No.3, p.373-380. Illus. 34 ref.
Abstract The objective of this study was to evaluate the genotoxicity of solvents used in shoemaking. Thirty-four exposed Mexican shoe workers and 34 unexposed control subjects, paired by age and sex, were compared. Occupational exposure was determined by personal monitoring followed by gas chromatography. Exfoliated buccal cells of each subject were used to determine the incidence of micronuclei and other nuclear abnormalities. Solvents detected were acetone, ethyl acetate, butanone and toluene. The incidence of nuclear abnormalities was significantly higher in the exposed group. A positive relationship was found between the incidence of micronuclei and workplace toluene concentrations. The micronucleus test is proposed as a low cost biomarker of genotoxicity.
Descriptors (primary) Mexico; organic solvents; shoe industry; risk factors; genetic effects
Descriptors (secondary) genetic abnormalities; personal sampling; acetone; butanone; gas chromatography; toluene; exposure evaluation; dose-response relationship; ethyl acetate
Document type D - Periodical articles
Country / State or ProvinceMexico
Subject(s) Leather, fur and footwear
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Footwear, leather and fur industry
Genetic factors in reaction to exposures